Abstract
PURPOSE: To evaluate a new non-ablative and adjustable procedure for laser ablative refractive corneal surgery in hyperopia using the injection of a biocompatible liquid filler material into a stromal pocket.
METHODS: A total of 120 stromal pockets were created using a clinical femtosecond laser system in 96 rabbit corneoscleral discs and 24 whole globes. Pockets were cut at a depth of 120 or 250 μm below the epithelial surface. Hyaluronic acid was injected manually into the pocket. To determine the refractive changes, three-dimensional optical coherence tomography images and a specifically developed picture recognition Mat- lab (The Mathworks) routine were used.
RESULTS: After injection, a steepening of the anterior and flattening of the posterior corneal surface was observed, which led to hyperopic correction. The two main factors de- termining the amount of correction were the pocket depth and the injected volume. After the pocket was homogeneously filled, an initial refractive increase was observed, followed by a linear relation between the injected volume and the re- fraction increase.
CONCLUSIONS: This possible clinical protocol for controlled refraction correction of hyperopia suggests a potential readjustable clinical application.
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@article{Wertheimer2020,
title = {Refractive Changes After Corneal Stromal Filler Injection for the Correction of Hyperopia},
author = {Christian M Wertheimer and Katharina Brandt and Steffen Kaminsky and Carolin Elhardt and Stefan A Kassumeh and Linh Pham and Hinnerk Schulz-Hildebrandt and Siegfried Priglinger and Rox R Anderson and Reginald Birngruber},
doi = {10.3928/1081597X-20200429-01},
year = {2020},
date = {2020-06-14},
journal = {Journal of Refractive Surgery},
volume = {36},
number = {6},
pages = {406--413},
abstract = {PURPOSE: To evaluate a new non-ablative and adjustable procedure for laser ablative refractive corneal surgery in hyperopia using the injection of a biocompatible liquid filler material into a stromal pocket.
METHODS: A total of 120 stromal pockets were created using a clinical femtosecond laser system in 96 rabbit corneoscleral discs and 24 whole globes. Pockets were cut at a depth of 120 or 250 μm below the epithelial surface. Hyaluronic acid was injected manually into the pocket. To determine the refractive changes, three-dimensional optical coherence tomography images and a specifically developed picture recognition Mat- lab (The Mathworks) routine were used.
RESULTS: After injection, a steepening of the anterior and flattening of the posterior corneal surface was observed, which led to hyperopic correction. The two main factors de- termining the amount of correction were the pocket depth and the injected volume. After the pocket was homogeneously filled, an initial refractive increase was observed, followed by a linear relation between the injected volume and the re- fraction increase.
CONCLUSIONS: This possible clinical protocol for controlled refraction correction of hyperopia suggests a potential readjustable clinical application.
},
keywords = {},
pubstate = {published},
tppubtype = {article}
}