Hinnerk Schulz-Hildebrandt

@article{Jaeckle2021c,

title = {3D Stent Graft Guidance based on Tracking Systems for Endovascular Aneurysm Repair:},

author = {Sonja J\"{a}ckle and Tim Eixmann and Florian Matysiak and Malte Maria Sieren and Marco Horn and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Torben P\"{a}tz},

url = {https://doi.org/10.1515/cdbme-2021-1004},

doi = {doi:10.1515/cdbme-2021-1004},

year  = {2021},

date = {2021-01-01},

urldate = {2021-01-01},

journal = {Current Directions in Biomedical Engineering},

volume = {7},

number = {1},

pages = {17--20},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{CEREDA2021100085,

title = {Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery},

author = {Matteo Giuseppe Cereda and Salvatore Parrulli and Y G M Douven and Koorosh Faridpooya and Saskia Romunde and Gereon H\"{u}ttmann and Tim Eixmann and Hinnerk Schulz-Hildebrandt and Gernot Kronreif and Maarten Beelen and Marc D Smet},

url = {https://www.sciencedirect.com/science/article/pii/S2666914521000750},

doi = {https://doi.org/10.1016/j.xops.2021.100085},

issn = {2666-9145},

year  = {2021},

date = {2021-01-01},

journal = {Ophthalmology Science},

volume = {1},

number = {4},

pages = {100085},

abstract = {Purpose 

To assess the efficacy of an instrument-integrated OCT (iiOCT)-based distance sensor during robotic vitreoretinal surgery using the Preceyes Surgical System (PSS; Preceyes B.V.). 

Design 

Single-center interventional study. 

Participants 

Patients requiring vitreoretinal surgery. 

Methods 

Five patients were enrolled. Standard preoperative OCT images were obtained. After vitrectomy, a predefined set of actions was performed using the iiOCT-based sensor. Images then were processed to assess the signal-to-noise ratio (SNR) at various angles to the retina and at different distances between the instrument tip and the retinal surface. Preoperative and intraoperative OCT images were compared qualitatively and quantitatively. 

Main Outcomes Measures 

The feasibility in performing surgical tasks using the iiOCT-based sensor during vitreoretinal surgery, the SNR when imaging the retina, differences among intraoperative and preoperative OCT images, and characteristics of intraoperative retinal movements detected with the iiOCT-based probe. 

Results 

Surgeons were able to perform all the tasks but one. The PSS was able to maintain a fixed distance. The SNR of the iiOCT-based sensor signal was adequate to determine the distance to the retina and to control the PSS. Analysis of iiOCT-based sensor A-scans identified 3 clearly distinguishable retinal layers, including the inner retinal boundary and the interface at the retinal pigment epithelium\textendashBruch's membrane. Thickness values differed by less than 5% from that measured by preoperative OCT, indicating its accuracy. The Fourier analysis of iiOCT-based sensor recordings identified anteroposterior retinal movements attributed to heartbeat and respiration. 

Conclusions 

This iiOCT-based sensor was tested successfully and promises reliable use during robot-assisted surgery. An iiOCT-based sensor is a promising step toward OCT-guided robotic retinal surgery.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{SIEREN2021,

title = {Radiation-free Thoracic Endovascular Aneurysm Repair with Fiberoptic and Electromagnetic Guidance:A Phantom Study},

author = {Malte Maria Sieren and Sonja J\"{a}ckle and Tim Eixmann and Hinnerk Schulz-Hildebrandt and Florian Matysiak and Mark Preuss and Ver\'{o}nica Garc\'{i}a-V\'{a}zquez and Erik Stahlberg and Markus Kleemann and J\"{o}rg Barkhausen and Jan Goltz and Marco Horn},

url = {https://www.sciencedirect.com/science/article/pii/S1051044321016079},

doi = {https://doi.org/10.1016/j.jvir.2021.12.025},

issn = {1051-0443},

year  = {2021},

date = {2021-01-01},

journal = {Journal of Vascular and Interventional Radiology},

abstract = {Purpose 

The purpose of this study was to evaluate the feasibility and accuracy of a radiation-free implantation of a thoracic aortic stent-graft employing fiberoptic and electromagnetic tracking in an anthropomorphic phantom. 

Materials and Methods 

An anthropomorphic phantom was manufactured based on computed tomography angiography (CTA) data from a patient. An aortic stent-graft application system was equipped with a fiber Bragg gratings fiber and three electromagnetic sensors. The stent-graft was navigated in the phantom by three interventionalists using the tracking data generated by both technologies. One implantation procedure was performed. The technical success of the procedure was evaluated using digital subtraction angiography and pre- and post-interventional CTA. Tracking accuracy was determined at various anatomical landmarks based on separately acquired fluoroscopic images. The mean/maximum errors were measured for the stent-graft application system and the tip/end of the stent-graft. 

Results 

The procedure resulted in technical success with a mean error below 3 mm for the entire application system and \<2 mm for the position of the tip of the stent-graft. Navigation/implantation and handling of the device were rated sufficiently accurate and on a par with comparable, routinely used stent-graft application systems. 

Conclusion 

Our study demonstrates successful stent-graft implantation during a thoracic endovascular aortic repair procedure employing advanced guidance techniques and avoiding fluoroscopic imaging. This is an essential step in facilitating the implantation of stent-grafts and reducing the health risks associated with ionizing radiation during endovascular procedures.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Schneider2020,

title = {An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations},

author = {Hartmut Schneider and Martin Ahrens and Michaela Strumpski and Claudia R\"{u}ger and Matthias H\"{a}fer and Gereon H\"{u}ttmann and Dirk Theisen-Kunde and Hinnerk Schulz-Hildebrandt and Rainer Haak},

url = {https://www.mdpi.com/852930},

doi = {10.3390/JCM9103257},

year  = {2020},

date = {2020-10-01},

journal = {Journal of Clinical Medicine 2020, Vol. 9, Page 3257},

volume = {9},

number = {10},

pages = {3257},

publisher = {Multidisciplinary Digital Publishing Institute},

abstract = {Caries, the world\’s most common chronic disease, remains a major cause of invasive restorative dental treatment. To take advantage of the diagnostic potential of optical coherence tomography (OCT) in contemporary dental prevention and treatment, an intraorally applicable spectral-domain OCT probe has been developed based on an OCT hand-held scanner equipped with a rigid 90\°-optics endoscope. The probe was verified in vitro. In vivo, all tooth surfaces could be imaged with the OCT probe, except the vestibular surfaces of third molars and the proximal surface sections of molars within a "blind spot" at a distance greater than 2.5 mm from the tooth surface. Proximal surfaces of 64 posterior teeth of four volunteers were assessed by intraoral OCT, visual-tactile inspection, bitewing radiography and fiber-optic transillumination. The agreement in detecting healthy and carious surfaces varied greatly between OCT and established methods (18.2-94.7%), whereby the established methods could always be supplemented by OCT. Direct and indirect composite and ceramic restorations with inherent imperfections and failures of the tooth-restoration bond were imaged and qualitatively evaluated. The intraoral OCT probe proved to be a powerful technological approach for the non-invasive imaging of healthy and carious hard tooth tissues and gingiva as well as tooth-colored restorations.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Munter:20,

title = {Dynamic contrast in scanning microscopic OCT},

author = {Michael M\"{u}nter and Malte vom Endt and Mario Pieper and Malte Casper and Martin Ahrens and Tabea Kohlfaerber and Ramtin Rahmanzadeh and Peter K\"{o}nig and Gereon H\"{u}ttmann and Hinnerk Schulz-Hildebrandt},

url = {http://ol.osa.org/abstract.cfm?URI=ol-45-17-4766},

doi = {10.1364/OL.396134},

year  = {2020},

date = {2020-09-01},

journal = {Opt. Lett.},

volume = {45},

number = {17},

pages = {4766--4769},

publisher = {OSA},

abstract = {While optical coherence tomography (OCT) provides a resolution downto 1 textmum, it has difficulties in visualizing cellular structures due to alack of scattering contrast. By evaluating signal fluctuations, asignificant contrast enhancement was demonstrated using time-domainfull-field OCT (FF-OCT), which makes cellular and subcellular structuresvisible. The putative cause of the dynamic OCT signal is thesite-dependent active motion of cellular structures in a sub-micrometerrange, which provides histology-like contrast. Here we demonstrate dynamiccontrast with a scanning frequency-domain OCT (FD-OCT), which we believehas crucial advantages. Given the inherent sectional imaging geometry,scanning FD-OCT provides depth-resolved images across tissue layers, aperspective known from histopathology, much faster and more efficientlythan FF-OCT. Both shorter acquisition times and tomographicdepth-sectioning reduce the sensitivity of dynamic contrast for bulktissue motion artifacts and simplify their correction in post-processing.Dynamic contrast makes microscopic FD-OCT a promising tool for thehistological analysis of unstained tissues.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Wertheimer2020,

title = {Refractive Changes After Corneal Stromal Filler Injection for the Correction of Hyperopia},

author = {Christian M Wertheimer and Katharina Brandt and Steffen Kaminsky and Carolin Elhardt and Stefan A Kassumeh and Linh Pham and Hinnerk Schulz-Hildebrandt and Siegfried Priglinger and Rox R Anderson and Reginald Birngruber},

doi = {10.3928/1081597X-20200429-01},

year  = {2020},

date = {2020-06-14},

journal = {Journal of Refractive Surgery},

volume = {36},

number = {6},

pages = {406--413},

abstract = {PURPOSE: To evaluate a new non-ablative and adjustable procedure for laser ablative refractive corneal surgery in hyperopia using the injection of a biocompatible liquid filler material into a stromal pocket.

METHODS: A total of 120 stromal pockets were created using a clinical femtosecond laser system in 96 rabbit corneoscleral discs and 24 whole globes. Pockets were cut at a depth of 120 or 250 μm below the epithelial surface. Hyaluronic acid was injected manually into the pocket. To determine the refractive changes, three-dimensional optical coherence tomography images and a specifically developed picture recognition Mat- lab (The Mathworks) routine were used.

RESULTS: After injection, a steepening of the anterior and flattening of the posterior corneal surface was observed, which led to hyperopic correction. The two main factors de- termining the amount of correction were the pocket depth and the injected volume. After the pocket was homogeneously filled, an initial refractive increase was observed, followed by a linear relation between the injected volume and the re- fraction increase.

CONCLUSIONS: This possible clinical protocol for controlled refraction correction of hyperopia suggests a potential readjustable clinical application.

},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{doi:10.1002/cyto.a.24012,

title = {Coregistered Spectral Optical Coherence Tomography and Two-Photon Microscopy for Multimodal Near-Instantaneous Deep-Tissue Imaging},

author = {Asylkhan Rakhymzhan and Lucie Reuter and Raphael Raspe and Daniel Bremer and Robert G\"{u}nther and Ruth Leben and Judith Heidelin and Volker Andresen and Sergey Cheremukhin and Hinnerk Schulz-Hildebrandt and Maria G Bixel and Ralf H Adams and Helena Radbruch and Gereon H\"{u}ttmann and Anja E Hauser and Raluca A Niesner},

url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/cyto.a.24012},

doi = {10.1002/cyto.a.24012},

year  = {2020},

date = {2020-04-14},

journal = {Cytometry Part A},

volume = {97},

number = {5},

pages = {515-527},

abstract = {Abstract Two-photon microscopy (2PM) has brought unique insight into the mechanisms underlying immune system dynamics and function since it enables monitoring of cellular motility and communication in complex systems within their genuine environment\^{a}€”the living organism. However, use of 2PM in clinical settings is limited. In contrast, optical coherence tomography (OCT), a noninvasive label-free diagnostic imaging method, which allows monitoring morphologic changes of large tissue regions in vivo, has found broad application in the clinic. Here we developed a combined multimodal technology to achieve near-instantaneous coregistered OCT, 2PM, and second harmonic generation (SHG) imaging over large volumes (up to 1,000\^{a}€‰\~{A}—\^{a}€‰1,000\^{a}€‰\~{A}—\^{a}€‰300\^{a}€‰\^{I}\OEm3) of tendons and other tissue compartments in mouse paws, as well as in mouse lymph nodes, spleens, and femurs. Using our multimodal imaging approach, we found differences in macrophage cell shape and motility behavior depending on whether they are located in tendons or in the surrounding tissue compartments of the mouse paw. The cellular shape of tissue-resident macrophages, indicative for their role in tissue, correlated with the supramolecular organization of collagen as revealed by SHG and OCT. Hence, the here-presented approach of coregistered OCT and 2PM has the potential to link specific cellular phenotypes and functions (as revealed by 2PM) to tissue morphology (as highlighted by OCT) and thus, to build a bridge between basic research knowledge and clinical observations. \^{A}© 2020 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of International Society for Advancement of Cytometry.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}