2019
|
Marco Horn; Sonja Jäckle; Felix von Haxthausen; Tim Eixmann; Hinnerk Schulz-Hildebrandt; Gereon Hüttmann; Juljan Bouchagiar; Florian Matysiak; Mark Kaschwich; Markus Kleemann; Floris Ernst; Verónica García-Vázquez; Torben Pätz First Steps into Catheter Guidance Including Shape Sensing for Endovascular Aneurysm Repair Procedures Proceedings W.B. Saunders, vol. 58, no. 6, 2019, ISSN: 1078-5884. @proceedings{Horn2019b,
title = {First Steps into Catheter Guidance Including Shape Sensing for Endovascular Aneurysm Repair Procedures},
author = {Marco Horn and Sonja J\"{a}ckle and Felix von Haxthausen and Tim Eixmann and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Juljan Bouchagiar and Florian Matysiak and Mark Kaschwich and Markus Kleemann and Floris Ernst and Ver\'{o}nica Garc\'{i}a-V\'{a}zquez and Torben P\"{a}tz},
doi = {10.1016/J.EJVS.2019.09.091},
issn = {1078-5884},
year = {2019},
date = {2019-12-13},
journal = {European Journal of Vascular and Endovascular Surgery},
volume = {58},
number = {6},
pages = {e610--e611},
publisher = {W.B. Saunders},
keywords = {},
pubstate = {published},
tppubtype = {proceedings}
}
|
Casper, M. J.; Glahn, J.; Evers, M.; Schulz-Hildebrandt, H.; Kositratna, G.; Birngruber, R.; Hüttmann, G.; Manstein, D. Capillary Refill - The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography Journal Article In: Lasers in Surgery and Medicine, 2019. @article{Casper2019b,
title = {Capillary Refill - The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography},
author = {Casper, M. J. and Glahn, J. and Evers, M. and Schulz-Hildebrandt, H. and Kositratna, G. and Birngruber, R. and H\"{u}ttmann, G. and Manstein, D.},
doi = {10.1002/lsm.23188},
year = {2019},
date = {2019-11-22},
journal = {Lasers in Surgery and Medicine},
abstract = {Background/Objectives Standard optical coherence tomography angiography (OCTA) has been limited to imaging blood vessels actively undergoing perfusion, providing a temporary picture of surface microvasculature. Capillary perfusion in the skin is dynamic and changes in response to the surrounding tissue's respiratory, nutritional, and thermoregulatory needs. Hence, OCTA often represents a given perfusion state without depicting the actual extent of the vascular network. Here we present a method for obtaining a more accurate anatomic representation of the surface capillary network in human skin using OCTA, along with proposing a new parameter, the Relative Capillary Capacity (RCC), a quantifiable proxy for assessing capillary dilation potential and permeability. Methods OCTA images were captured at baseline and after compression of the skin. Baseline images display ambient capillary perfusion, while images taken upon capillary refill display the network of existing capillaries at full capacity. An optimization-based automated vessel segmentation method was used to automatically analyze and compare OCTA image sequences obtained from two volunteers. RCC was then compared with visual impressions of capillary viability. Results Our OCTA imaging sequence provides a method for mapping cutaneous capillary networks independent of ambient perfusion. Differences between baseline and refill images clearly demonstrate the shortcomings of standard OCTA imaging and produce the RCC biometric as a quantifiable proxy for assessing capillary dilation potential and permeability. Conclusion Future dermatological OCTA diagnostic studies should implement the Capillary Refill Methods over standard imaging techniques and further explore the relevance of RCC to differential diagnosis and dermatopathology.
\textbf{Lasers Surg. Med. © The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals, Inc.}},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background/Objectives Standard optical coherence tomography angiography (OCTA) has been limited to imaging blood vessels actively undergoing perfusion, providing a temporary picture of surface microvasculature. Capillary perfusion in the skin is dynamic and changes in response to the surrounding tissue's respiratory, nutritional, and thermoregulatory needs. Hence, OCTA often represents a given perfusion state without depicting the actual extent of the vascular network. Here we present a method for obtaining a more accurate anatomic representation of the surface capillary network in human skin using OCTA, along with proposing a new parameter, the Relative Capillary Capacity (RCC), a quantifiable proxy for assessing capillary dilation potential and permeability. Methods OCTA images were captured at baseline and after compression of the skin. Baseline images display ambient capillary perfusion, while images taken upon capillary refill display the network of existing capillaries at full capacity. An optimization-based automated vessel segmentation method was used to automatically analyze and compare OCTA image sequences obtained from two volunteers. RCC was then compared with visual impressions of capillary viability. Results Our OCTA imaging sequence provides a method for mapping cutaneous capillary networks independent of ambient perfusion. Differences between baseline and refill images clearly demonstrate the shortcomings of standard OCTA imaging and produce the RCC biometric as a quantifiable proxy for assessing capillary dilation potential and permeability. Conclusion Future dermatological OCTA diagnostic studies should implement the Capillary Refill Methods over standard imaging techniques and further explore the relevance of RCC to differential diagnosis and dermatopathology.
Lasers Surg. Med. © The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals, Inc. |
Tabea Kohlfaerber; Shujun Ding; Ramtin Rahmanzadeh; Thomas Jüngst; Jürgen Groll; Hinnerk Schulz-Hildebrandt; Gereon Hüttmann Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT Proceedings vol. 1, no. 1, 2019. @proceedings{Kohlfaerber2019b,
title = {Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT},
author = {Tabea Kohlfaerber and Shujun Ding and Ramtin Rahmanzadeh and Thomas J\"{u}ngst and J\"{u}rgen Groll and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann},
doi = {10.18416/AMMM.2019.1909S03P19},
year = {2019},
date = {2019-11-21},
journal = {Transactions on Additive Manufacturing Meets Medicine},
volume = {1},
number = {1},
abstract = {Optical coherence tomography is a non-invasive and label-free imaging modality based on the detection of backscattered light in samples. As microscopic OCT (mOCT) combines high axial and lateral resolution, an investigation of biological and printed samples at subcellular level is feasible. The additional excellent depth resolution enables mOCT to be a suitable quality control of 3D printed samples. The use of speckle variance adds information about cell viability. Here we present the feasibility of investigating cell viability within a cell spheroid and monitoring the cell interaction with bioprinted scaffolds using mOCT.},
keywords = {},
pubstate = {published},
tppubtype = {proceedings}
}
Optical coherence tomography is a non-invasive and label-free imaging modality based on the detection of backscattered light in samples. As microscopic OCT (mOCT) combines high axial and lateral resolution, an investigation of biological and printed samples at subcellular level is feasible. The additional excellent depth resolution enables mOCT to be a suitable quality control of 3D printed samples. The use of speckle variance adds information about cell viability. Here we present the feasibility of investigating cell viability within a cell spheroid and monitoring the cell interaction with bioprinted scaffolds using mOCT. |
Sonja Jäckle; Tim Eixmann; Hinnerk Schulz-Hildebrandt; Gereon Hüttmann; Torben Pätz Fiber optical shape sensing of flexible instruments for endovascular navigation Journal Article In: International Journal of Computer Assisted Radiology and Surgery, 2019, ISSN: 1861-6429. @article{J\"{a}ckle2019,
title = {Fiber optical shape sensing of flexible instruments for endovascular navigation},
author = {Sonja J\"{a}ckle and Tim Eixmann and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Torben P\"{a}tz},
url = {https://doi.org/10.1007/s11548-019-02059-0},
doi = {10.1007/s11548-019-02059-0},
issn = {1861-6429},
year = {2019},
date = {2019-09-01},
journal = {International Journal of Computer Assisted Radiology and Surgery},
abstract = {Endovascular aortic repair procedures are currently conducted with 2D fluoroscopy imaging. Tracking systems based on fiber Bragg gratings are an emerging technology for the navigation of minimally invasive instruments which can reduce the X-ray exposure and the used contrast agent. Shape sensing of flexible structures is challenging and includes many calculations steps which are prone to different errors. To reduce this errors, we present an optimized shape sensing model.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Endovascular aortic repair procedures are currently conducted with 2D fluoroscopy imaging. Tracking systems based on fiber Bragg gratings are an emerging technology for the navigation of minimally invasive instruments which can reduce the X-ray exposure and the used contrast agent. Shape sensing of flexible structures is challenging and includes many calculations steps which are prone to different errors. To reduce this errors, we present an optimized shape sensing model. |
Malte Casper, Hinnerk Schulz-Hildebrandt, Michael Evers, Reginald Birngruber, Dieter Manstein, Gereon Hüttmann Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography Journal Article In: Journal of Biomedical Optics, vol. 24, no. 4, pp. 46005 - 1 - 11, 2019. @article{Casper2019,
title = {Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography},
author = {Malte Casper, Hinnerk Schulz-Hildebrandt, Michael Evers, Reginald Birngruber, Dieter Manstein, Gereon H\"{u}ttmann},
doi = {10.1117/1.JBO.24.4.046005},
year = {2019},
date = {2019-04-30},
journal = {Journal of Biomedical Optics},
volume = {24},
number = {4},
pages = {46005 - 1 - 11},
abstract = {We present an endoscopic probe for optical coherence tomography (OCT) equipped with a miniaturized hollow ultrasonic motor that rotates the objective lens and provides an internal channel for the fiber to pass through, enabling 360 deg unobstructed circumferential scanning. This probe has an outer diameter of 1.5 mm, which is ultra-small for motorized probes with an unobstructed view in distal scanning endoscopic OCT. Instead of a mirror or prism, a customized aspheric right-angle lens is utilized, leading to an enlargement of the numerical aperture and thus high transverse resolution. Spectral-domain OCT imaging of bio-tissue and a phantom are demonstrated with resolution of 7.5 μm(axial) × 6.6 μm (lateral) and sensitivity of 96 dB.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
We present an endoscopic probe for optical coherence tomography (OCT) equipped with a miniaturized hollow ultrasonic motor that rotates the objective lens and provides an internal channel for the fiber to pass through, enabling 360 deg unobstructed circumferential scanning. This probe has an outer diameter of 1.5 mm, which is ultra-small for motorized probes with an unobstructed view in distal scanning endoscopic OCT. Instead of a mirror or prism, a customized aspheric right-angle lens is utilized, leading to an enlargement of the numerical aperture and thus high transverse resolution. Spectral-domain OCT imaging of bio-tissue and a phantom are demonstrated with resolution of 7.5 μm(axial) × 6.6 μm (lateral) and sensitivity of 96 dB. |
Michael Münter; Hinnerk Schulz-Hildebrandt; Mario Pieper; Peter König; Gereon Hüttmann 4D microscopic optical coherence tomography imaging of ex vivo mucus transport Proceedings Article In: Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, pp. 1–5, 2019, ISBN: 9781510628496. @inproceedings{Munter2019,
title = {4D microscopic optical coherence tomography imaging of ex vivo mucus transport},
author = {Michael M\"{u}nter and Hinnerk Schulz-Hildebrandt and Mario Pieper and Peter K\"{o}nig and Gereon H\"{u}ttmann},
url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11078/2527138/4D-microscopic-optical-coherence-tomography-imaging-of-ex-vivo-mucus/10.1117/12.2527138.full},
doi = {10.1117/12.2527138},
isbn = {9781510628496},
year = {2019},
date = {2019-01-01},
booktitle = {Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III},
volume = {11078},
number = {11},
pages = {1--5},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Martin Ahrens; Christian Idel; Adam Chaker; Barbara Wollenberg; Peter König; Hinnerk Schulz-Hildebrandt; Gereon Hüttmann An endomicroscopic OCT for clinical trials in the field of ENT (Invited) Proceedings Article In: Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II, pp. 1–4, 2019, ISBN: 9781510628397. @inproceedings{Ahrens2019,
title = {An endomicroscopic OCT for clinical trials in the field of ENT (Invited)},
author = {Martin Ahrens and Christian Idel and Adam Chaker and Barbara Wollenberg and Peter K\"{o}nig and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann},
url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11073/2527099/An-endomicroscopic-OCT-for-clinical-trials-in-the-field-of/10.1117/12.2527099.full},
doi = {10.1117/12.2527099},
isbn = {9781510628397},
year = {2019},
date = {2019-01-01},
booktitle = {Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II},
number = {110730U},
pages = {1--4},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Rainer Haak; Martin Ahrens; Hartmut Schneider; Michaela Strumpski; Claudia Rueger; Matthias Haefer; Gereon Hüttmann; Dirk Theisen-Kunde; Hinnerk Schulz-Hildebrandt Handheld OCT probe for intraoral diagnosis on teeth Proceedings Article In: Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II, pp. 1–4, 2019, ISBN: 9781510628397. @inproceedings{Haak2019,
title = {Handheld OCT probe for intraoral diagnosis on teeth},
author = {Rainer Haak and Martin Ahrens and Hartmut Schneider and Michaela Strumpski and Claudia Rueger and Matthias Haefer and Gereon H\"{u}ttmann and Dirk Theisen-Kunde and Hinnerk Schulz-Hildebrandt},
url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11073/2527185/Handheld-OCT-probe-for-intraoral-diagnosis-on-teeth/10.1117/12.2527185.full},
doi = {10.1117/12.2527185},
isbn = {9781510628397},
year = {2019},
date = {2019-01-01},
booktitle = {Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II},
number = {110730W},
pages = {1--4},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
|
Hinnerk Schulz-Hildebrandt; Naja Meyer-Schell; Malte Casper; Michael Evers; Reginald Birngruber; Dieter Manstein; Gereon Hüttmann Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe Proceedings Article In: Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II, pp. 1–3, 2019, ISBN: 9781510628397. @inproceedings{Schulz-Hildebrandt2019,
title = {Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe},
author = {Hinnerk Schulz-Hildebrandt and Naja Meyer-Schell and Malte Casper and Michael Evers and Reginald Birngruber and Dieter Manstein and Gereon H\"{u}ttmann},
url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11073/2527087/Monitoring-temperature-induced-phase-changes-in-subcutaneous-fatty-tissue-using/10.1117/12.2527087.full},
doi = {10.1117/12.2527087},
isbn = {9781510628397},
year = {2019},
date = {2019-01-01},
booktitle = {Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II},
number = {110730L},
pages = {1--3},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
|
2018
|
Jonas Smits; Mouloud Ourak; Andy Gijbels; Laure Esteveny; Gianni Borghesan; Laurent Schoevaerdts; K. Willekens P. Stalmans E. Lankenau Hinnerk Schulz-Hildebrandt; Gereon Hüttmann; Dominiek Reynaerts; Emmanuel B. Vander Poorten Development and Experimental Validation of a Combined FBG Force and OCT Distance Sensing Needle for Robot-Assisted Retinal Vein Cannulation Proceedings Article In: pp. 129-134, 2018. @inproceedings{Smits2018,
title = {Development and Experimental Validation of a Combined FBG Force and OCT Distance Sensing Needle for Robot-Assisted Retinal Vein Cannulation},
author = {Jonas Smits and Mouloud Ourak and Andy Gijbels and Laure Esteveny and Gianni Borghesan and Laurent Schoevaerdts and K. Willekens P. Stalmans E. Lankenau Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Dominiek Reynaerts and Emmanuel B. Vander Poorten},
url = {https://doi.org/10.1109/ICRA.2018.8460983},
doi = {10.1109/ICRA.2018.8460983},
year = {2018},
date = {2018-09-20},
journal = {2018 IEEE International Conference on Robotics and Automation (ICRA)},
pages = {129-134},
abstract = {Retinal Vein Occlusion is a common retinal vascular disorder which can cause severe loss of vision. Retinal vein cannulation followed by injection of an anti-coagulant into the affected vein is a promising treatment. However, given the scale and fragility of the surgical workfield, this procedure is considered too high-risk to perform manually. A first successful robot-assisted procedure has been demonstrated. Even though successful, the procedure remains extremely challenging. This paper aims at providing a solution for the limited perception of instrument-tissue interaction forces as well as depth estimation during retinal vein cannulation. The development of a novel combined force and distance sensing cannulation needle relying on Fiber Bragg grating (FBG) and Optical Coherence Tomography (OCT) A-scan technology is reported. The design, the manufacturing process, the calibration method, and the experimental characterization of the produced sensor are discussed.
The functionality of the combined sensing modalities and the real-time distance estimation algorithm are validated respectively on in-vitro and ex-vivo models.},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
Retinal Vein Occlusion is a common retinal vascular disorder which can cause severe loss of vision. Retinal vein cannulation followed by injection of an anti-coagulant into the affected vein is a promising treatment. However, given the scale and fragility of the surgical workfield, this procedure is considered too high-risk to perform manually. A first successful robot-assisted procedure has been demonstrated. Even though successful, the procedure remains extremely challenging. This paper aims at providing a solution for the limited perception of instrument-tissue interaction forces as well as depth estimation during retinal vein cannulation. The development of a novel combined force and distance sensing cannulation needle relying on Fiber Bragg grating (FBG) and Optical Coherence Tomography (OCT) A-scan technology is reported. The design, the manufacturing process, the calibration method, and the experimental characterization of the produced sensor are discussed.
The functionality of the combined sensing modalities and the real-time distance estimation algorithm are validated respectively on in-vitro and ex-vivo models. |